Peptide Protocol Library
Explore 54+ evidence-based peptide protocols across 8 categories. Research summaries, safety profiles, and clinical applications — reviewed by practitioners.
Growth Hormone Optimization
12 protocols
Healing & Recovery
5 protocols
Weight Management
7 protocols
Sexual Health
4 protocols
Cognitive Enhancement
8 protocols
Immune & Longevity
11 protocols
Hair & Skin
3 protocols
Hormone Support
4 protocols
Growth Hormone Optimization
12 protocols
CJC-1295 (with DAC)
ResearchedGrowth hormone releasing hormone (GHRH) analog with Drug Affinity Complex (DAC) that extends half-life to ~8 days. Stimulates pituitary to release GH in a pulsatile fashion.
CJC-1295 (no DAC) / Mod GRF 1-29
ResearchedGHRH analog without DAC. Shorter half-life (~30 min) creates more natural pulsatile GH release.
Ipamorelin
ResearchedSelective ghrelin receptor agonist (GH secretagogue). Stimulates GH release from pituitary without significantly affecting cortisol, ACTH, or prolactin.
Tesamorelin
ResearchedSynthetic GHRH analog. FDA-approved for HIV-associated lipodystrophy. Potent stimulator of endogenous GH production.
MK-677 (Ibutamoren)
ResearchedOral ghrelin mimetic. Stimulates GH secretion via ghrelin receptor. Long-acting (24h half-life).
GHRP-2
ResearchedSynthetic hexapeptide GHRP. Acts on ghrelin receptor to stimulate GH release. More potent GH release than GHRP-6 but also increases cortisol and prolactin.
Hexarelin
ResearchedPotent growth hormone releasing peptide (GHRP) that binds ghrelin receptors to stimulate GH release. Stronger GH release than GHRP-2 but with more cortisol and prolactin elevation.
GHRP-6
ResearchedFirst-generation GHRP that stimulates ghrelin receptors to release growth hormone. Also strongly stimulates appetite via ghrelin pathway activation.
Sermorelin
ResearchedBioidentical GHRH analog consisting of the first 29 amino acids of endogenous GHRH. Stimulates natural pulsatile GH release from the pituitary without suppressing endogenous production.
IGF-1 LR3
ResearchedModified IGF-1 with extended half-life (20-30 hours vs 15 minutes for native IGF-1). Binds IGF-1 receptors with reduced affinity for IGF binding proteins, resulting in higher bioavailability and potent anabolic effects.
Follistatin 344
EmergingActivin-binding glycoprotein that neutralizes myostatin, the primary negative regulator of muscle growth. By blocking myostatin, allows enhanced muscle hypertrophy and reduces adipose tissue.
PEG-MGF
EmergingPEGylated form of Mechano Growth Factor, a splice variant of IGF-1 produced in response to mechanical loading. PEGylation extends half-life. Activates satellite cells for muscle repair and hypertrophy.
Healing & Recovery
5 protocols
BPC-157
ResearchedGastric pentadecapeptide that promotes angiogenesis, upregulates growth factor receptors (VEGF, FGF), modulates nitric oxide system, and promotes tendon and ligament healing. Cytoprotective for GI mucosa.
TB-500
ResearchedSynthetic fragment of Thymosin Beta-4. Promotes cell migration, angiogenesis, and reduces inflammation. Upregulates actin to promote cell motility for wound healing.
GHK-Cu
ResearchedNaturally occurring copper-binding tripeptide. Activates wound healing, stimulates collagen and elastin synthesis, promotes stem cell activity, and has broad anti-aging gene expression effects.
Pentosan Polysulfate (PPS)
ResearchedSemi-synthetic heparinoid with anti-inflammatory and cartilage-protective properties. Stimulates proteoglycan synthesis in cartilage and inhibits complement activation.
TB-500 Fragment (Ac-SDKP)
EmergingTetrapeptide fragment of Thymosin Beta-4 with potent anti-fibrotic and anti-inflammatory properties. Inhibits TGF-beta signaling, reduces fibrosis, and promotes angiogenesis without full TB-500 immune effects.
Weight Management
7 protocols
Semaglutide
ResearchedGLP-1 receptor agonist. Mimics incretin hormone to reduce appetite, slow gastric emptying, and improve insulin sensitivity. Acts on hypothalamic appetite centers.
Tirzepatide
ResearchedDual GIP/GLP-1 receptor agonist. Combines two incretin pathways for enhanced metabolic effects. Superior weight loss and glycemic control vs GLP-1 alone.
AOD-9604
EmergingModified fragment of human growth hormone (amino acids 177-191). Mimics fat-burning action of GH without affecting blood sugar or growth.
5-Amino-1MQ
EmergingNNMT (nicotinamide N-methyltransferase) inhibitor. Blocks enzyme that contributes to fat storage and metabolic dysfunction. Increases NAD+ levels in fat cells.
Retatrutide
EmergingTriple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Provides superior weight loss through appetite reduction, increased energy expenditure, and improved glucose metabolism.
MOTS-c
EmergingMitochondria-derived peptide that activates AMPK pathway, enhances glucose uptake, improves insulin sensitivity, and promotes fatty acid oxidation. Acts as an exercise mimetic.
CagriSema
EmergingFixed-ratio combination of cagrilintide (amylin analog) and semaglutide (GLP-1 agonist). Dual mechanism targets appetite, satiety, and gastric emptying through complementary pathways.
Sexual Health
4 protocols
PT-141 (Bremelanotide)
ResearchedMelanocortin receptor agonist (MC3R/MC4R). Acts on central nervous system to increase sexual arousal and desire. Unlike PDE5 inhibitors, works on desire rather than mechanics.
Kisspeptin-10
EmergingNeuropeptide that stimulates GnRH release from hypothalamus. Key regulator of reproductive hormone axis. Increases LH and FSH.
Oxytocin
ResearchedNeuropeptide hormone that facilitates social bonding, trust, and sexual arousal. Enhances orgasm intensity and reduces refractory period. Also has anxiolytic and stress-reducing effects.
Melanotan II
ResearchedNon-selective melanocortin receptor agonist that stimulates melanogenesis (skin tanning) and activates MC4R in the brain to increase sexual arousal and libido. Also reduces appetite.
Cognitive Enhancement
8 protocols
Selank
ResearchedSynthetic analog of tuftsin (immunomodulatory peptide). Modulates GABA, serotonin, dopamine, and norepinephrine. Anxiolytic without sedation. Increases BDNF.
Semax
ResearchedSynthetic analog of ACTH(4-10). Neuroprotective peptide that increases BDNF, NGF, and modulates dopamine/serotonin. Enhances attention and memory formation.
Dihexa
ExperimentalAngiotensin IV analog. Activates hepatocyte growth factor (HGF) system. Promotes synaptogenesis and neuronal connectivity. ~10 million times more potent than BDNF at forming new synapses.
DSIP
EmergingEndogenous neuropeptide that promotes delta wave sleep. Modulates cortisol and has stress-protective effects. Normalizes sleep architecture.
PE-22-28
ExperimentalTREK-1 potassium channel blocker. Produces rapid antidepressant effects similar to mechanism of action proposed for some novel antidepressants.
Cortexin
EmergingComplex of low-molecular-weight neuropeptides derived from cerebral cortex. Provides neurotrophic support, enhances neuronal metabolism, and improves cognitive function through GABAergic and glutamatergic modulation.
NSI-189
ExperimentalBenzylpiperazine-aminopyridine compound that stimulates neurogenesis in the hippocampus. Increases hippocampal volume and enhances synaptic plasticity, potentially reversing depression-related brain atrophy.
P21 (CNTF Fragment)
ExperimentalSmall molecule derivative of ciliary neurotrophic factor (CNTF). Enhances neurogenesis and inhibits tau hyperphosphorylation by increasing BDNF and inhibiting leukemia inhibitory factor (LIF) signaling.
Immune & Longevity
11 protocols
Thymosin Alpha-1
ResearchedThymic peptide hormone that enhances T-cell maturation, dendritic cell function, and immune surveillance. Modulates both innate and adaptive immunity.
Epithalon
EmergingSynthetic tetrapeptide based on epithalamin (pineal gland extract). Activates telomerase, promoting telomere elongation. Regulates melatonin production and circadian rhythm.
LL-37
EmergingHuman cathelicidin antimicrobial peptide. Part of innate immune system. Directly kills bacteria, fungi, and viruses. Also modulates inflammation and promotes wound healing.
KPV
EmergingC-terminal tripeptide of alpha-MSH. Potent anti-inflammatory effects via NF-kB pathway inhibition. Modulates gut inflammation.
Thymalin
EmergingPolypeptide complex extracted from calf thymus. Restores thymic function, modulates T-cell immunity, and has demonstrated anti-aging effects through immune system rejuvenation.
SS-31 (Elamipretide)
EmergingMitochondria-targeted peptide that binds cardiolipin in the inner mitochondrial membrane. Stabilizes cristae structure, improves electron transport chain efficiency, and reduces reactive oxygen species.
FOXO4-DRI
ExperimentalSenolytic peptide that disrupts the FOXO4-p53 interaction in senescent cells. Forces senescent cells to undergo apoptosis while sparing healthy cells, effectively clearing "zombie cells" from tissues.
Humanin (HNG)
EmergingMitochondria-derived peptide that protects cells from apoptosis and oxidative stress. Activates STAT3 and ERK signaling, improves insulin sensitivity, and has potent cytoprotective effects on neurons and cardiomyocytes.
Thymalfasin (Zadaxin)
ResearchedPharmaceutical-grade Thymosin Alpha-1. Enhances dendritic cell maturation, T-cell differentiation, and NK cell activity. Modulates immune response without immunosuppression — upregulates when needed, calms when overactive.
NMN (Nicotinamide Mononucleotide)
ResearchedDirect precursor to NAD+ (nicotinamide adenine dinucleotide). Rapidly converted to NAD+ via the salvage pathway, restoring cellular energy metabolism, DNA repair, sirtuin activation, and mitochondrial function that decline with age.
NAD+ IV Therapy
EmergingDirect intravenous infusion of NAD+ bypasses oral absorption limitations, rapidly elevating cellular NAD+ levels. Supports mitochondrial function, DNA repair, sirtuin activation, and cellular energy production.
Hair & Skin
3 protocols
Copper Peptide AHK-Cu
EmergingTripeptide-copper complex that stimulates hair follicle growth by increasing follicle size and prolonging anagen phase. Also promotes wound healing and collagen synthesis through copper-dependent enzyme activation.
Palmitoyl Pentapeptide-4 (Matrixyl)
ResearchedSignal peptide that mimics collagen breakdown products (matrikines). Stimulates fibroblasts to produce collagen I, III, and IV, fibronectin, and glycosaminoglycans in the skin matrix.
Biotinoyl Tripeptide-1
EmergingBiotin-conjugated peptide that strengthens hair follicle anchoring in the dermal papilla. Reduces follicle aging by improving metabolic activity and blood flow to hair follicles.
Hormone Support
4 protocols
Gonadorelin
ResearchedSynthetic GnRH (gonadotropin-releasing hormone). Stimulates pituitary to release LH and FSH. Used to maintain fertility during TRT.
Kisspeptin-54
ResearchedFull-length kisspeptin that activates GPR54 receptors in the hypothalamus to stimulate GnRH release. Potent stimulator of the entire HPG axis including LH, FSH, and downstream sex hormones.
Enclomiphene
ResearchedSelective estrogen receptor modulator (SERM) — the active trans-isomer of clomiphene. Blocks estrogen feedback at the hypothalamus/pituitary, increasing LH and FSH to boost endogenous testosterone production.
Anastrozole
ResearchedPotent non-steroidal aromatase inhibitor that blocks conversion of testosterone to estradiol. Used in HRT protocols to manage estrogen levels in men on testosterone therapy.
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This protocol library is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting any peptide therapy. Specific dosing protocols require a BioRoot AI Pro subscription.