Peptide Protocol Library

Explore 54+ evidence-based peptide protocols across 8 categories. Research summaries, safety profiles, and clinical applications — reviewed by practitioners.

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Growth Hormone Optimization

12 protocols

CJC-1295 (with DAC)

Researched

Growth hormone releasing hormone (GHRH) analog with Drug Affinity Complex (DAC) that extends half-life to ~8 days. Stimulates pituitary to release GH in a pulsatile fashion.

Anti-agingFat lossMuscle growth+3 more

CJC-1295 (no DAC) / Mod GRF 1-29

Researched

GHRH analog without DAC. Shorter half-life (~30 min) creates more natural pulsatile GH release.

Anti-agingFat lossMuscle growth+2 more

Ipamorelin

Researched

Selective ghrelin receptor agonist (GH secretagogue). Stimulates GH release from pituitary without significantly affecting cortisol, ACTH, or prolactin.

Anti-agingFat lossMuscle growth+3 more

Tesamorelin

Researched

Synthetic GHRH analog. FDA-approved for HIV-associated lipodystrophy. Potent stimulator of endogenous GH production.

Visceral fat reductionAnti-agingCognitive function+1 more

MK-677 (Ibutamoren)

Researched

Oral ghrelin mimetic. Stimulates GH secretion via ghrelin receptor. Long-acting (24h half-life).

GH elevationSleep qualityMuscle preservation+2 more

GHRP-2

Researched

Synthetic hexapeptide GHRP. Acts on ghrelin receptor to stimulate GH release. More potent GH release than GHRP-6 but also increases cortisol and prolactin.

GH elevationMuscle growthFat loss+1 more

Hexarelin

Researched

Potent growth hormone releasing peptide (GHRP) that binds ghrelin receptors to stimulate GH release. Stronger GH release than GHRP-2 but with more cortisol and prolactin elevation.

Growth hormone releaseMuscle growthFat loss+2 more

GHRP-6

Researched

First-generation GHRP that stimulates ghrelin receptors to release growth hormone. Also strongly stimulates appetite via ghrelin pathway activation.

Growth hormone releaseAppetite stimulationMuscle growth+2 more

Sermorelin

Researched

Bioidentical GHRH analog consisting of the first 29 amino acids of endogenous GHRH. Stimulates natural pulsatile GH release from the pituitary without suppressing endogenous production.

Growth hormone optimizationAnti-agingImproved sleep+2 more

IGF-1 LR3

Researched

Modified IGF-1 with extended half-life (20-30 hours vs 15 minutes for native IGF-1). Binds IGF-1 receptors with reduced affinity for IGF binding proteins, resulting in higher bioavailability and potent anabolic effects.

Muscle growthRecoveryFat loss+2 more

Follistatin 344

Emerging

Activin-binding glycoprotein that neutralizes myostatin, the primary negative regulator of muscle growth. By blocking myostatin, allows enhanced muscle hypertrophy and reduces adipose tissue.

Muscle growthMyostatin inhibitionFat loss+2 more

PEG-MGF

Emerging

PEGylated form of Mechano Growth Factor, a splice variant of IGF-1 produced in response to mechanical loading. PEGylation extends half-life. Activates satellite cells for muscle repair and hypertrophy.

Muscle repairMuscle growthRecovery from injury+2 more
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Healing & Recovery

5 protocols

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Weight Management

7 protocols

Semaglutide

Researched

GLP-1 receptor agonist. Mimics incretin hormone to reduce appetite, slow gastric emptying, and improve insulin sensitivity. Acts on hypothalamic appetite centers.

Weight lossType 2 diabetesAppetite suppression+2 more

Tirzepatide

Researched

Dual GIP/GLP-1 receptor agonist. Combines two incretin pathways for enhanced metabolic effects. Superior weight loss and glycemic control vs GLP-1 alone.

Weight lossType 2 diabetesMetabolic health+1 more

AOD-9604

Emerging

Modified fragment of human growth hormone (amino acids 177-191). Mimics fat-burning action of GH without affecting blood sugar or growth.

Fat lossBody compositionCartilage repair

5-Amino-1MQ

Emerging

NNMT (nicotinamide N-methyltransferase) inhibitor. Blocks enzyme that contributes to fat storage and metabolic dysfunction. Increases NAD+ levels in fat cells.

Fat lossMetabolic healthNAD+ boosting+1 more

Retatrutide

Emerging

Triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Provides superior weight loss through appetite reduction, increased energy expenditure, and improved glucose metabolism.

Weight lossObesity treatmentType 2 diabetes+2 more

MOTS-c

Emerging

Mitochondria-derived peptide that activates AMPK pathway, enhances glucose uptake, improves insulin sensitivity, and promotes fatty acid oxidation. Acts as an exercise mimetic.

Metabolic optimizationFat lossExercise performance+2 more

CagriSema

Emerging

Fixed-ratio combination of cagrilintide (amylin analog) and semaglutide (GLP-1 agonist). Dual mechanism targets appetite, satiety, and gastric emptying through complementary pathways.

Weight lossObesityType 2 diabetes+1 more
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Sexual Health

4 protocols

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Cognitive Enhancement

8 protocols

Selank

Researched

Synthetic analog of tuftsin (immunomodulatory peptide). Modulates GABA, serotonin, dopamine, and norepinephrine. Anxiolytic without sedation. Increases BDNF.

Anxiety reductionCognitive enhancementFocus+2 more

Semax

Researched

Synthetic analog of ACTH(4-10). Neuroprotective peptide that increases BDNF, NGF, and modulates dopamine/serotonin. Enhances attention and memory formation.

Cognitive enhancementNeuroprotectionFocus+3 more

Dihexa

Experimental

Angiotensin IV analog. Activates hepatocyte growth factor (HGF) system. Promotes synaptogenesis and neuronal connectivity. ~10 million times more potent than BDNF at forming new synapses.

Cognitive enhancementNeuroplasticityMemory+1 more

DSIP

Emerging

Endogenous neuropeptide that promotes delta wave sleep. Modulates cortisol and has stress-protective effects. Normalizes sleep architecture.

Sleep improvementInsomniaStress reduction+2 more

PE-22-28

Experimental

TREK-1 potassium channel blocker. Produces rapid antidepressant effects similar to mechanism of action proposed for some novel antidepressants.

DepressionMood enhancementAntidepressant effects

Cortexin

Emerging

Complex of low-molecular-weight neuropeptides derived from cerebral cortex. Provides neurotrophic support, enhances neuronal metabolism, and improves cognitive function through GABAergic and glutamatergic modulation.

Cognitive enhancementNeuroprotectionStroke recovery+2 more

NSI-189

Experimental

Benzylpiperazine-aminopyridine compound that stimulates neurogenesis in the hippocampus. Increases hippocampal volume and enhances synaptic plasticity, potentially reversing depression-related brain atrophy.

DepressionCognitive enhancementHippocampal neurogenesis+2 more

P21 (CNTF Fragment)

Experimental

Small molecule derivative of ciliary neurotrophic factor (CNTF). Enhances neurogenesis and inhibits tau hyperphosphorylation by increasing BDNF and inhibiting leukemia inhibitory factor (LIF) signaling.

Cognitive enhancementNeurogenesisAlzheimer prevention+2 more
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Immune & Longevity

11 protocols

Thymosin Alpha-1

Researched

Thymic peptide hormone that enhances T-cell maturation, dendritic cell function, and immune surveillance. Modulates both innate and adaptive immunity.

Immune enhancementChronic infectionsCancer adjunct therapy+3 more

Epithalon

Emerging

Synthetic tetrapeptide based on epithalamin (pineal gland extract). Activates telomerase, promoting telomere elongation. Regulates melatonin production and circadian rhythm.

Anti-agingTelomere lengtheningSleep regulation+2 more

LL-37

Emerging

Human cathelicidin antimicrobial peptide. Part of innate immune system. Directly kills bacteria, fungi, and viruses. Also modulates inflammation and promotes wound healing.

AntimicrobialImmune defenseBiofilm disruption+2 more

KPV

Emerging

C-terminal tripeptide of alpha-MSH. Potent anti-inflammatory effects via NF-kB pathway inhibition. Modulates gut inflammation.

Gut inflammationIBD supportAutoimmune modulation+2 more

Thymalin

Emerging

Polypeptide complex extracted from calf thymus. Restores thymic function, modulates T-cell immunity, and has demonstrated anti-aging effects through immune system rejuvenation.

Immune restorationAnti-agingCancer adjunct+2 more

SS-31 (Elamipretide)

Emerging

Mitochondria-targeted peptide that binds cardiolipin in the inner mitochondrial membrane. Stabilizes cristae structure, improves electron transport chain efficiency, and reduces reactive oxygen species.

Mitochondrial optimizationAnti-agingHeart failure+2 more

FOXO4-DRI

Experimental

Senolytic peptide that disrupts the FOXO4-p53 interaction in senescent cells. Forces senescent cells to undergo apoptosis while sparing healthy cells, effectively clearing "zombie cells" from tissues.

Senescent cell clearanceAnti-agingTissue rejuvenation+2 more

Humanin (HNG)

Emerging

Mitochondria-derived peptide that protects cells from apoptosis and oxidative stress. Activates STAT3 and ERK signaling, improves insulin sensitivity, and has potent cytoprotective effects on neurons and cardiomyocytes.

NeuroprotectionAnti-agingCardiovascular protection+2 more

Thymalfasin (Zadaxin)

Researched

Pharmaceutical-grade Thymosin Alpha-1. Enhances dendritic cell maturation, T-cell differentiation, and NK cell activity. Modulates immune response without immunosuppression — upregulates when needed, calms when overactive.

Immune modulationHepatitis B/C adjunctCancer immunotherapy adjunct+2 more

NMN (Nicotinamide Mononucleotide)

Researched

Direct precursor to NAD+ (nicotinamide adenine dinucleotide). Rapidly converted to NAD+ via the salvage pathway, restoring cellular energy metabolism, DNA repair, sirtuin activation, and mitochondrial function that decline with age.

NAD+ restorationAnti-agingEnergy metabolism+3 more

NAD+ IV Therapy

Emerging

Direct intravenous infusion of NAD+ bypasses oral absorption limitations, rapidly elevating cellular NAD+ levels. Supports mitochondrial function, DNA repair, sirtuin activation, and cellular energy production.

Rapid NAD+ restorationAnti-agingAddiction recovery+3 more

Hair & Skin

3 protocols

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Hormone Support

4 protocols

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This protocol library is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting any peptide therapy. Specific dosing protocols require a BioRoot AI Pro subscription.