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MK-677 (Ibutamoren)

Also known as: Ibutamoren, Nutrobal

Well ResearchedGrowth Hormone Optimization

How It Works

Oral ghrelin mimetic. Stimulates GH secretion via ghrelin receptor. Long-acting (24h half-life).

What It's Used For

GH elevationSleep qualityMuscle preservationAnti-agingAppetite stimulation

Administration

Route: Oral

Typical Cycle: 8-12 weeks on, 4 weeks off (or continuous low dose under supervision)

Safety & Side Effects

Possible Side Effects

⚠Increased appetite
⚠Water retention
⚠Elevated blood glucose
⚠Lethargy
⚠Numbness/tingling

Contraindications

✘Diabetes/insulin resistance
✘Active cancer
✘Pregnancy

Research Summary

Oral GH secretagogue with 24h activity. Increases IGF-1 by ~40-90%. Concerns about insulin resistance with prolonged use.

References

Murphy MG et al. J Clin Endocrinol Metab. 1998

Legal & Availability

Research chemical

Dosing Protocol

Standard: 10-25mg daily

Frequency: Once daily

Timing: Before bed (reduces impact of hunger side effect)

Notes: Oral administration. Can increase blood glucose - monitor in pre-diabetics.

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

CJC-1295 (no DAC) / Mod GRF 1-29

Anti-aging, Fat loss

BPC-157

Injury repair, Gut healing

Full stacking protocols and cycling schedules available with Pro subscription.

Is MK-677 (Ibutamoren) Right for You?

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.