NSI-189
Also known as: NSI-189 Phosphate
How It Works
Benzylpiperazine-aminopyridine compound that stimulates neurogenesis in the hippocampus. Increases hippocampal volume and enhances synaptic plasticity, potentially reversing depression-related brain atrophy.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Headache
- ⚠Insomnia
- ⚠Mild GI discomfort
- ⚠Vivid dreams
Contraindications
- ✘Bipolar disorder
- ✘Seizure disorders
- ✘Pregnancy
- ✘Concurrent MAOI use
Research Summary
Novel neurogenic compound showing hippocampal volume increases in Phase 2 depression trials. Unique mechanism distinct from traditional antidepressants. Mixed efficacy results but strong biomarker data.
References
- Fava M et al. Mol Psychiatry. 2016
- McIntyre RS et al. J Clin Psychopharmacol. 2020
Legal & Availability
Investigational / Research chemical
This peptide requires a prescription from a licensed provider.
Dosing Protocol
Stacks Well With
Selank
Anxiety reduction, Cognitive enhancement
Semax
Cognitive enhancement, Neuroprotection
Dihexa
Cognitive enhancement, Neuroplasticity
Full stacking protocols and cycling schedules available with Pro subscription.
Is NSI-189 Right for You?
Our AI analyzes your symptoms, labs, and medical history to determine if this peptide fits your protocol — and at what dose.
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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.