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Enclomiphene

Also known as: Androxal, Trans-clomiphene

Well ResearchedHormone SupportProvider Rx Required

How It Works

Selective estrogen receptor modulator (SERM) — the active trans-isomer of clomiphene. Blocks estrogen feedback at the hypothalamus/pituitary, increasing LH and FSH to boost endogenous testosterone production.

What It's Used For

Testosterone optimizationMale hypogonadismFertility preservationPost-TRT recoveryEstrogen management

Administration

Route: Oral

Typical Cycle: Ongoing or cycled 3 months on/1 month off

Safety & Side Effects

Possible Side Effects

⚠Headache
⚠Hot flashes
⚠Visual disturbances (rare)
⚠Mood changes

Contraindications

✘Liver disease
✘DVT/PE history
✘Hormone-sensitive cancers
✘Pregnancy

Research Summary

Shown to restore testosterone to normal range in secondary hypogonadism while preserving fertility — a key advantage over TRT. Multiple Phase 3 trials completed with strong efficacy data.

References

Wiehle RD et al. Clin Endocrinol. 2014
Kim ED et al. BJU Int. 2016

Legal & Availability

Compounding pharmacy with prescription / Not yet FDA-approved as standalone

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 12.5-25mg per dose

Frequency: Once daily

Timing: Morning

Notes: Unlike clomiphene, lacks the estrogenic zu-isomer — fewer side effects

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

Gonadorelin

Fertility preservation on TRT, Testicular function maintenance

Full stacking protocols and cycling schedules available with Pro subscription.

Is Enclomiphene Right for You?

Our AI analyzes your symptoms, labs, and medical history to determine if this peptide fits your protocol — and at what dose.

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.