PT-141 (Bremelanotide)
Also known as: Bremelanotide, Vyleesi
How It Works
Melanocortin receptor agonist (MC3R/MC4R). Acts on central nervous system to increase sexual arousal and desire. Unlike PDE5 inhibitors, works on desire rather than mechanics.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Nausea (very common, ~40%)
- ⚠Flushing
- ⚠Headache
- ⚠Skin hyperpigmentation (with repeated use)
- ⚠Hypertension (transient)
Contraindications
- ✘Uncontrolled hypertension
- ✘Cardiovascular disease
- ✘Pregnancy
Research Summary
FDA-approved for hypoactive sexual desire disorder in premenopausal women (Vyleesi). Also used off-label in men. Unique mechanism acting on central arousal pathways.
References
- Kingsberg SA et al. Obstet Gynecol. 2019
Legal & Availability
FDA-approved (prescription)
This peptide requires a prescription from a licensed provider.
Dosing Protocol
Standard: 1.75mg per dose (women, FDA approved) / 1-2mg (men, off-label)
Frequency: As needed, max 1 dose per 24 hours
Timing: 45 minutes before anticipated activity
Notes: Do not use more than 8 doses per month. Can cause significant nausea.
Is PT-141 (Bremelanotide) Right for You?
Our AI analyzes your symptoms, labs, and medical history to determine if this peptide fits your protocol — and at what dose.
Is PT-141 (Bremelanotide) right for you?
Get a free personalized analysis based on your symptoms and goals — delivered to your inbox.
This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.