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SS-31 (Elamipretide)

Also known as: Elamipretide, Bendavia, MTP-131

Emerging ResearchImmune & LongevityProvider Rx Required

How It Works

Mitochondria-targeted peptide that binds cardiolipin in the inner mitochondrial membrane. Stabilizes cristae structure, improves electron transport chain efficiency, and reduces reactive oxygen species.

What It's Used For

Mitochondrial optimizationAnti-agingHeart failureKidney protectionExercise performance

Administration

Route: Subcutaneous injection, Intravenous infusion

Typical Cycle: 4-8 weeks, then maintenance

Safety & Side Effects

Possible Side Effects

⚠Injection site reactions
⚠Transient renal effects at high doses

Contraindications

✘Severe kidney disease
✘Pregnancy

Research Summary

Breakthrough mitochondrial therapeutic in late-stage clinical trials for Barth syndrome and heart failure. Shown to improve mitochondrial function, reduce oxidative stress, and improve cardiac output.

References

Szeto HH. Antioxid Redox Signal. 2014
Butler J et al. Circ Heart Fail. 2023

Legal & Availability

Investigational / Compassionate use programs

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 0.25mg/kg per dose

Frequency: Once daily

Timing: Morning

Notes: Clinical trials used IV infusion; subcutaneous being explored

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

MOTS-c

Metabolic optimization, Fat loss

Epithalon

Anti-aging, Telomere lengthening

Full stacking protocols and cycling schedules available with Pro subscription.

Is SS-31 (Elamipretide) Right for You?

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.