FOXO4-DRI
Also known as: FOXO4-D-Retro-Inverso, Proxofim
How It Works
Senolytic peptide that disrupts the FOXO4-p53 interaction in senescent cells. Forces senescent cells to undergo apoptosis while sparing healthy cells, effectively clearing "zombie cells" from tissues.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Theoretical: impaired wound healing
- ⚠Unknown long-term effects
Contraindications
- ✘Active wound healing
- ✘Pregnancy
- ✘Immune compromise
- ✘Post-surgery
Research Summary
Groundbreaking senolytic peptide. Mice studies showed restored fitness, fur regrowth, and improved renal function in aged animals. Considered one of the most promising anti-aging interventions.
References
- Baar MP et al. Cell. 2017
Legal & Availability
Research chemical — very limited availability
This peptide requires a prescription from a licensed provider.
Dosing Protocol
Standard: 5mg/kg (animal dose — human equivalent being studied)
Frequency: 3x per week for 3 weeks
Timing: Any time
Notes: Very early stage — dosing for humans not established
Stacks Well With
Epithalon
Anti-aging, Telomere lengthening
Thymalin
Immune restoration, Anti-aging
SS-31 (Elamipretide)
Mitochondrial optimization, Anti-aging
Full stacking protocols and cycling schedules available with Pro subscription.
Is FOXO4-DRI Right for You?
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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.