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NMN (Nicotinamide Mononucleotide)

Also known as: NMN, Beta-NMN, Nicotinamide Mononucleotide

Well ResearchedImmune & Longevity

How It Works

Direct precursor to NAD+ (nicotinamide adenine dinucleotide). Rapidly converted to NAD+ via the salvage pathway, restoring cellular energy metabolism, DNA repair, sirtuin activation, and mitochondrial function that decline with age.

What It's Used For

NAD+ restorationAnti-agingEnergy metabolismDNA repairCognitive functionExercise performance

Administration

Route: Oral, Sublingual, Intravenous infusion
Typical Cycle: Continuous daily use

Safety & Side Effects

Possible Side Effects

  • ⚠Mild GI discomfort
  • ⚠Flushing (less than niacin)
  • ⚠Insomnia if taken late

Contraindications

  • ✘Active cancer (NAD+ may fuel cancer cell metabolism)
  • ✘Pregnancy

Research Summary

Landmark studies by David Sinclair at Harvard showed NMN reverses age-related decline in mice. Human trials (METRO study) confirmed NAD+ elevation and improved muscle function. One of the most studied longevity interventions.

References

  • Yoshino J et al. Science. 2011
  • Igarashi M et al. NPJ Aging. 2022
  • Yi L et al. GeroScience. 2023

Legal & Availability

Dietary supplement (FDA status varies by country; available OTC in most markets)

Dosing Protocol

Standard: 250-1000mg per dose

Frequency: Once daily

Timing: Morning on empty stomach

Notes: Sublingual or IV forms have higher bioavailability than oral capsules

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

Epithalon

Anti-aging, Telomere lengthening

SS-31 (Elamipretide)

Mitochondrial optimization, Anti-aging

MOTS-c

Metabolic optimization, Fat loss

Humanin (HNG)

Neuroprotection, Anti-aging

Full stacking protocols and cycling schedules available with Pro subscription.

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.