Palmitoyl Pentapeptide-4 (Matrixyl)
Also known as: Matrixyl, Pal-KTTKS
How It Works
Signal peptide that mimics collagen breakdown products (matrikines). Stimulates fibroblasts to produce collagen I, III, and IV, fibronectin, and glycosaminoglycans in the skin matrix.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Rare skin irritation
- ⚠Allergic reaction (very rare)
Contraindications
- ✘Known sensitivity to cosmetic ingredients
Research Summary
One of the best-studied cosmetic peptides. Double-blind studies show significant wrinkle depth reduction comparable to retinol but without irritation. Widely used in anti-aging skincare.
References
- Robinson LR et al. Int J Cosmet Sci. 2005
- Lintner K et al. Int J Cosmet Sci. 2009
Legal & Availability
Available OTC as cosmetic ingredient
Dosing Protocol
Standard: 2-4% in topical formulation
Frequency: Twice daily
Timing: Morning and evening after cleansing
Notes: Widely available in cosmeceutical formulations
Stacks Well With
Full stacking protocols and cycling schedules available with Pro subscription.
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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.