🛡️

Humanin (HNG)

Also known as: HNG, S14G-Humanin, Humanin Analog

Emerging ResearchImmune & LongevityProvider Rx Required

How It Works

Mitochondria-derived peptide that protects cells from apoptosis and oxidative stress. Activates STAT3 and ERK signaling, improves insulin sensitivity, and has potent cytoprotective effects on neurons and cardiomyocytes.

What It's Used For

NeuroprotectionAnti-agingCardiovascular protectionInsulin sensitivityMitochondrial support

Administration

Route: Subcutaneous injection

Typical Cycle: 8-12 weeks

Safety & Side Effects

Possible Side Effects

⚠Injection site reactions
⚠Limited human safety data

Contraindications

✘Pregnancy
✘Active cancer (anti-apoptotic concern)

Research Summary

Mitochondrial-derived peptide with broad cytoprotective effects. Circulating levels decline with age and correlate with Alzheimer risk. Animal studies show protection against neurodegeneration, atherosclerosis, and diabetes.

References

Hashimoto Y et al. Proc Natl Acad Sci. 2001
Yen K et al. Aging Cell. 2020

Legal & Availability

Research chemical

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 1-4mg per dose

Frequency: 3-5x per week

Timing: Morning

Notes: HNG (S14G mutation) is 1000x more potent than native humanin

🔒

Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

MOTS-c

Metabolic optimization, Fat loss

SS-31 (Elamipretide)

Mitochondrial optimization, Anti-aging

Epithalon

Anti-aging, Telomere lengthening

Full stacking protocols and cycling schedules available with Pro subscription.

Is Humanin (HNG) Right for You?

Our AI analyzes your symptoms, labs, and medical history to determine if this peptide fits your protocol — and at what dose.

Is Humanin (HNG) right for you?

Get a free personalized analysis based on your symptoms and goals — delivered to your inbox.

This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.