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TB-500 Fragment (Ac-SDKP)

Also known as: Ac-SDKP, TB4 Fragment, N-acetyl-seryl-aspartyl-lysyl-proline

Emerging ResearchHealing & Recovery

How It Works

Tetrapeptide fragment of Thymosin Beta-4 with potent anti-fibrotic and anti-inflammatory properties. Inhibits TGF-beta signaling, reduces fibrosis, and promotes angiogenesis without full TB-500 immune effects.

What It's Used For

Anti-fibrotic therapyCardiac fibrosisKidney fibrosisWound healingInflammation reduction

Administration

Route: Subcutaneous injection

Typical Cycle: 4-8 weeks

Safety & Side Effects

Possible Side Effects

⚠Injection site reactions
⚠Mild headache

Contraindications

✘Active cancer
✘Pregnancy

Research Summary

Endogenous tetrapeptide released by ACE2. Studies show potent anti-fibrotic effects in cardiac, renal, and pulmonary fibrosis models. Under investigation as standalone anti-fibrotic therapeutic.

References

Sharma U et al. Peptides. 2016
Rasoul S et al. PLoS One. 2012

Legal & Availability

Research chemical

Dosing Protocol

Standard: 100-500mcg per dose

Frequency: Once daily

Timing: Any time

Notes: Naturally produced by ACE2 enzyme; levels decline with ACE inhibitor use

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

BPC-157

Injury repair, Gut healing

TB-500

Tissue repair, Wound healing

GHK-Cu

Skin rejuvenation, Wound healing

Full stacking protocols and cycling schedules available with Pro subscription.

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.