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MOTS-c

Also known as: Mitochondrial ORF of the 12S rRNA Type-C

Emerging ResearchWeight Management

How It Works

Mitochondria-derived peptide that activates AMPK pathway, enhances glucose uptake, improves insulin sensitivity, and promotes fatty acid oxidation. Acts as an exercise mimetic.

What It's Used For

Metabolic optimizationFat lossExercise performanceInsulin sensitivityLongevity

Administration

Route: Subcutaneous injection
Typical Cycle: 8-12 weeks on, 4 weeks off

Safety & Side Effects

Possible Side Effects

  • ⚠Injection site reactions
  • ⚠Mild fatigue initially
  • ⚠Hypoglycemia (rare)

Contraindications

  • ✘Hypoglycemia
  • ✘Pregnancy
  • ✘Active cancer (theoretical)

Research Summary

Novel mitochondrial-derived peptide with exercise-mimetic properties. Human studies show improved glucose metabolism and insulin sensitivity. Declining levels correlate with aging.

References

  • Lee C et al. Cell Metab. 2015
  • Reynolds JC et al. Aging Cell. 2021

Legal & Availability

Research chemical / Compounding pharmacy

Dosing Protocol

Standard: 5-10mg per dose

Frequency: 3-5x per week

Timing: Morning or pre-workout

Notes: Often cycled with exercise for synergistic effects

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

AOD-9604

Fat loss, Body composition

BPC-157

Injury repair, Gut healing

SS-31 (Elamipretide)

Mitochondrial optimization, Anti-aging

Full stacking protocols and cycling schedules available with Pro subscription.

Is MOTS-c Right for You?

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.