Tirzepatide
Also known as: Mounjaro, Zepbound
How It Works
Dual GIP/GLP-1 receptor agonist. Combines two incretin pathways for enhanced metabolic effects. Superior weight loss and glycemic control vs GLP-1 alone.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Nausea
- ⚠Diarrhea
- ⚠Constipation
- ⚠Vomiting
- ⚠Abdominal pain
- ⚠Injection site reactions
Contraindications
- ✘Personal/family history of medullary thyroid carcinoma
- ✘MEN 2 syndrome
- ✘Pancreatitis history
- ✘Pregnancy
Research Summary
FDA-approved dual GIP/GLP-1 agonist. SURMOUNT-1 showed up to 22.5% body weight reduction at highest dose. Currently the most effective pharmaceutical weight loss agent.
References
- Jastreboff AM et al. N Engl J Med. 2022 (SURMOUNT-1)
Legal & Availability
FDA-approved (prescription)
This peptide requires a prescription from a licensed provider.
Dosing Protocol
Standard: 2.5mg-15mg weekly (titrated up)
Frequency: Once weekly
Timing: Same day each week
Notes: Titrate: 2.5mg x4wk → 5mg x4wk → 7.5mg x4wk → 10mg x4wk → 12.5mg x4wk → 15mg
Stacks Well With
Full stacking protocols and cycling schedules available with Pro subscription.
Is Tirzepatide Right for You?
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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.