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PE-22-28

Also known as: Spadin analog

ExperimentalCognitive EnhancementProvider Rx Required

How It Works

TREK-1 potassium channel blocker. Produces rapid antidepressant effects similar to mechanism of action proposed for some novel antidepressants.

What It's Used For

DepressionMood enhancementAntidepressant effects

Administration

Route: Intranasal, Subcutaneous injection

Typical Cycle: 2-4 weeks

Safety & Side Effects

Possible Side Effects

⚠Limited data
⚠Potential for overstimulation

Contraindications

✘Seizure disorders
✘Pregnancy
✘Bipolar disorder (mania risk)

Research Summary

Rapid-acting antidepressant peptide based on TREK-1 channel blockade. Animal data shows antidepressant effects within days. Very limited human data.

References

Mazella J et al. PLoS One. 2010

Legal & Availability

Research chemical

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 50-200mcg per dose

Frequency: Daily

Timing: Morning

Notes: Experimental. Limited human data.

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

Selank

Anxiety reduction, Cognitive enhancement

Semax

Cognitive enhancement, Neuroprotection

Full stacking protocols and cycling schedules available with Pro subscription.

Is PE-22-28 Right for You?

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.