Retatrutide
Also known as: LY3437943, Reta
How It Works
Triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Provides superior weight loss through appetite reduction, increased energy expenditure, and improved glucose metabolism.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Nausea
- ⚠Diarrhea
- ⚠Vomiting
- ⚠Decreased appetite
- ⚠Constipation
Contraindications
- ✘Personal/family history of medullary thyroid carcinoma
- ✘MEN2 syndrome
- ✘Pancreatitis history
- ✘Pregnancy
Research Summary
Phase 2 trials showed up to 24% body weight loss at 48 weeks — the highest of any obesity medication to date. Triple receptor mechanism may offer advantages over dual agonists.
References
- Jastreboff AM et al. N Engl J Med. 2023
Legal & Availability
Investigational — not yet FDA-approved
This peptide requires a prescription from a licensed provider.
Dosing Protocol
Standard: 4-12mg weekly (titrated)
Frequency: Once weekly
Timing: Any time, consistent day
Notes: Dose escalation over 12-24 weeks to minimize GI side effects
Stacks Well With
Full stacking protocols and cycling schedules available with Pro subscription.
Is Retatrutide Right for You?
Our AI analyzes your symptoms, labs, and medical history to determine if this peptide fits your protocol — and at what dose.
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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.