Pentosan Polysulfate (PPS)
Also known as: Elmiron, Pentosan, PPS
How It Works
Semi-synthetic heparinoid with anti-inflammatory and cartilage-protective properties. Stimulates proteoglycan synthesis in cartilage and inhibits complement activation.
What It's Used For
Administration
Safety & Side Effects
Possible Side Effects
- ⚠Bruising at injection site
- ⚠Mild GI upset
- ⚠Headache
- ⚠Rare: retinal pigment changes with long-term oral use
Contraindications
- ✘Bleeding disorders
- ✘Anticoagulant therapy
- ✘Thrombocytopenia
- ✘Pregnancy
Research Summary
Well-established in veterinary medicine for joint disease. Increasing evidence in humans for osteoarthritis. FDA-approved oral form (Elmiron) for bladder conditions.
References
- Ghosh P. Semin Arthritis Rheum. 1999
- Kumagai K et al. BMC Musculoskelet Disord. 2010
Legal & Availability
Prescription required
This peptide requires a prescription from a licensed provider.
Dosing Protocol
Standard: 2mg/kg per dose
Frequency: Weekly
Timing: Any time
Notes: FDA-approved oral form for interstitial cystitis; injectable used for joint therapy
Stacks Well With
BPC-157
Injury repair, Gut healing
TB-500
Tissue repair, Wound healing
GHK-Cu
Skin rejuvenation, Wound healing
Full stacking protocols and cycling schedules available with Pro subscription.
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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.