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Kisspeptin-54

Also known as: Metastin, KP-54, Full-length Kisspeptin

Well ResearchedHormone SupportProvider Rx Required

How It Works

Full-length kisspeptin that activates GPR54 receptors in the hypothalamus to stimulate GnRH release. Potent stimulator of the entire HPG axis including LH, FSH, and downstream sex hormones.

What It's Used For

Fertility supportHypogonadismIVF protocolsLH/FSH stimulationPuberty disorders

Administration

Route: Intravenous infusion, Subcutaneous injection

Typical Cycle: Single dose or short protocol (fertility)

Safety & Side Effects

Possible Side Effects

⚠Hot flashes
⚠Nausea
⚠Headache
⚠Injection site reactions

Contraindications

✘Hormone-sensitive cancers
✘Pregnancy
✘Precocious puberty

Research Summary

Kisspeptin is the master regulator of reproductive hormone release. Clinical trials show it can trigger egg maturation in IVF without risk of ovarian hyperstimulation syndrome (OHSS).

References

Jayasena CN et al. J Clin Invest. 2014
Abbara A et al. J Clin Endocrinol Metab. 2015

Legal & Availability

Investigational / Research use

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 6.4nmol/kg IV or 1nmol/kg SC

Frequency: Single dose or short course

Timing: As directed by fertility specialist

Notes: Used primarily in fertility research protocols

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

Gonadorelin

Fertility preservation on TRT, Testicular function maintenance

Full stacking protocols and cycling schedules available with Pro subscription.

Is Kisspeptin-54 Right for You?

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.