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IGF-1 LR3

Also known as: Long R3 IGF-1, Insulin-like Growth Factor 1 Long R3

Well ResearchedGrowth Hormone OptimizationProvider Rx Required

How It Works

Modified IGF-1 with extended half-life (20-30 hours vs 15 minutes for native IGF-1). Binds IGF-1 receptors with reduced affinity for IGF binding proteins, resulting in higher bioavailability and potent anabolic effects.

What It's Used For

Muscle growthRecoveryFat lossAnti-agingTissue repair

Administration

Route: Subcutaneous injection, Intramuscular injection

Typical Cycle: 4-6 weeks on, 4 weeks off

Safety & Side Effects

Possible Side Effects

⚠Hypoglycemia
⚠Joint pain
⚠Gut growth (high doses)
⚠Water retention
⚠Jaw/hand growth (chronic high doses)

Contraindications

✘Active cancer
✘Diabetes (hypoglycemia risk)
✘Pregnancy

Research Summary

Potent anabolic peptide widely used in bodybuilding and anti-aging. Extended half-life allows once-daily dosing. Risk of hypoglycemia requires careful management. More potent than GH secretagogues for direct tissue growth.

References

Francis GL et al. J Mol Endocrinol. 1992

Legal & Availability

Research chemical / Prescription through compounding pharmacy

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 20-50mcg per dose

Frequency: Daily

Timing: Post-workout or morning

Notes: Bilateral injection to target muscle groups for localized growth

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

Ipamorelin

Anti-aging, Fat loss

CJC-1295 (no DAC) / Mod GRF 1-29

Anti-aging, Fat loss

BPC-157

Injury repair, Gut healing

Full stacking protocols and cycling schedules available with Pro subscription.

Is IGF-1 LR3 Right for You?

Our AI analyzes your symptoms, labs, and medical history to determine if this peptide fits your protocol — and at what dose.

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.