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Semaglutide

Also known as: Ozempic, Wegovy, Rybelsus

Well ResearchedWeight ManagementProvider Rx Required

How It Works

GLP-1 receptor agonist. Mimics incretin hormone to reduce appetite, slow gastric emptying, and improve insulin sensitivity. Acts on hypothalamic appetite centers.

What It's Used For

Weight lossType 2 diabetesAppetite suppressionCardiovascular risk reductionMetabolic health

Administration

Route: Subcutaneous injection, Oral (Rybelsus)

Typical Cycle: Long-term use (chronic condition management)

Safety & Side Effects

Possible Side Effects

⚠Nausea (very common)
⚠Vomiting
⚠Diarrhea
⚠Constipation
⚠Abdominal pain
⚠Fatigue
⚠Gallbladder issues
⚠Pancreatitis (rare)

Contraindications

✘Personal/family history of medullary thyroid carcinoma
✘MEN 2 syndrome
✘Pancreatitis history
✘Pregnancy
✘Severe GI disease

Research Summary

FDA-approved for weight management (Wegovy) and T2DM (Ozempic). STEP trials showed ~15% body weight loss. SELECT trial demonstrated cardiovascular benefit. Most studied and validated weight loss peptide.

References

Wilding JPH et al. N Engl J Med. 2021 (STEP 1)
Lincoff AM et al. N Engl J Med. 2023 (SELECT)

Legal & Availability

FDA-approved (prescription)

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 0.25mg-2.4mg weekly (titrated up)

Frequency: Once weekly

Timing: Same day each week, any time

Notes: MUST titrate slowly: 0.25mg x4wk → 0.5mg x4wk → 1.0mg x4wk → 1.7mg x4wk → 2.4mg. Rapid escalation causes severe GI side effects.

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

BPC-157

Injury repair, Gut healing

Full stacking protocols and cycling schedules available with Pro subscription.

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.