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P21 (CNTF Fragment)

Also known as: P021, CNTF Small Molecule Peptide

ExperimentalCognitive EnhancementProvider Rx Required

How It Works

Small molecule derivative of ciliary neurotrophic factor (CNTF). Enhances neurogenesis and inhibits tau hyperphosphorylation by increasing BDNF and inhibiting leukemia inhibitory factor (LIF) signaling.

What It's Used For

Cognitive enhancementNeurogenesisAlzheimer preventionMemory improvementNeuroprotection

Administration

Route: Intranasal, Subcutaneous injection

Typical Cycle: 4-8 weeks on, 4 weeks off

Safety & Side Effects

Possible Side Effects

⚠Nasal irritation
⚠Mild headache
⚠Very limited safety data

Contraindications

✘Pregnancy
✘Active seizure disorders

Research Summary

Promising neurogenic peptide showing rescue of cognitive deficits in Alzheimer mouse models. Increases dentate gyrus neurogenesis and reduces tau pathology. No human trials yet.

References

Bolognin S et al. J Alzheimers Dis. 2014
Li B et al. Neuroscience. 2010

Legal & Availability

Research chemical

This peptide requires a prescription from a licensed provider.

Dosing Protocol

Standard: 50-100mcg intranasal

Frequency: Once daily

Timing: Morning

Notes: Intranasal route for CNS delivery — oral bioavailability is low

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Unlock Full Dosing Protocol

Specific dosing, frequency, timing, cycling schedules, and stacking guidance are available with a BioRoot AI Pro subscription.

Stacks Well With

Semax

Cognitive enhancement, Neuroprotection

Selank

Anxiety reduction, Cognitive enhancement

Dihexa

Cognitive enhancement, Neuroplasticity

Full stacking protocols and cycling schedules available with Pro subscription.

Is P21 (CNTF Fragment) Right for You?

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This information is for educational purposes only and is not medical advice. Do not use any peptide without consulting a qualified healthcare provider. BioRoot AI is a clinical decision support tool — not a medical provider.